Researchers have just taken a step forward to understand Charcot’s disease (SLA), and have offered the hope of a new treatment to reduce its progress. He identified the involvement of hypothalamus and discovered that sleep changes were before the appearance of motor symptoms. He then tested an molecule that made it possible to preserve the motor neurons, restoring sleep with mice.
According to a French team, sleep disorders are already related to the presence of motor symptoms in Charcot. Is the treatment of sleep disorders a way to reduce the development of the disease? Scientists have observed this in mice.
To date, there is no cure for the treatment of Charcot, which causes the patient’s death within 3 to 5 years after the appearance of the disease. There Amotrophic Literal SclerosisAmotrophic Literal Sclerosis For,,,,,,,,,, for,, for,,,, for,,,, for,,, for,,,, for,,,, for,,,, for,,, for,,, for,,, for,,, for,,,, for,,, for,,, for,,,, for,,, for,,,, for,,, for,,, for,,,, for,,, for,,, for,,,, for,,, for,,,, for,,, for,,,, for,,, for,,,, for,,, for,,,, for,,,, for,,,, for,,,, for,,,, for,,,, for,,,, for,,, for,,, for,,, for,,, for,,,,, for,,,, for,,,, for,,,, for,, for,.SlapSlap) Or Charcott’s disease is a neurodegenerative disease associated with the progressive death of nerve cells, known as the Snow Mobiller. It is responsible for the progressive and rapid atrophy of the muscle, the appearance of motor disorders and the loss behind the lossAutonomyAutonomy The patient causes death muscle loss.
As many other neurodegenerative diseases are concerned, researchers at Ansum and the University of Strasbourg have surprised whether sleep disorders – due to the evolution of the disease – the motor disorders may already be present and if sleep rehabilitation evolution Can slow down. In this way, they analyzed dozens of sleep recording of groups of people with SLA at various stages of the disease – a group had not yet caused respiratory symptoms, the other was a beer of changes. GeneticsGenetics And presented the increasing risk of development of the disease. These results were compared to the control groups.
Hypothalamus involved in sleep disorders
« These tests show that two groups of individuals suffered the same type of sleep disorders: excessive awareness time and a amount of Deep sleepDeep sleep Below the data of control groups “Write the authors of this study in a press release published on Tuesday, February 4. Results, published in the newspaper Science Translator MedicineSuggest that many years before the manifestation of motor disorders, sleep disorders are present and observed.
Scientists then sought the origin of these sleep disorders in the brain. A track: Aurizen NeuronAurizen NeuronSpecific neurons ofHypothalamusHypothalamus I know to play a role ImpulsiveImpulsive Of the state of awareness. In the ALS mouse model, which observes the same sleep disorders, researchers discovered that neuron circuits where Oracean neurons are integrated, are replaced by the disappearance of the anxus neurons during the disease.
An intelligent molecule to slow the disease’s development
A UnrulyUnruly And the vaccine, which has already been proposed against Indira, has been given to sick mice. Results: Mice sleep is restored after taking the same oral. The activity of Orakson Neuron’s Inks Neuron was also restored, and after 15 days of treatment, mice saw the protection of motor neurons. The team of researchers now want to test molecules in SLA patients: Can their sleep be restored?
« The discoveries of our team are important at two levels. First, they put inside LightLight A new history of SLA symptoms, once again questioning the onset of the disease, and especially its role BrainBrain In her birthThe co -author of this study explains Lok Dopos. They also represent a slight hope for the sick, and those who declare the disease think that living in its first explanation can slow down its very rapid progress. ».
Do you know?
According to the Association for Research, the amyotrophic lettuce is related to 8,000 patients in France, or Charcott’s disease, or Charcot. There are 2.7 cases of 100,000 inhabitants in its annual events. It is a rare neurodegenerative pathology that is characterized by motor skills, the destruction of the neurons responsible for the snoo mobeller.
The disease is usually between 50 and 70 years. ALS is a progressive pathology that leads to death within 3 to 5 years after the first symbols. It is often the loss of respiratory muscle, which causes the patient’s death. It can show itself in the first 30 % of cases, describing or swallowing it. Otherwise, the disease may begin ” From a weakness and discomfort in the surface of an arm, a leg or a hand that appears on the beginning of the disease itself ».
The prediction of the disease:
- Contract, muscle and hardness of pairs;
- Muscle cast iron and coordination malfunction is embarrassing to walk, swallow and swallow or describe.
- At an advanced stage of the disease, respiratory muscles no longer manage to meet their function.