Professor Andrea is the head of the “natural immunity” head of the team Global Health Institute Switzerland’s Federal Polytechnic School of Luzon. In November 2024, he was awarded by the Lillian Bethencort Prize for the Living of Living. The price of a 100,000 euros, which has been allocated to the young researcher for his work, aims to understand the natural force of the immune response procedure in detail, and especially through the CGAS sting signaling route. Role played.
The natural immunity against external aggression creates the first blurk of our organization. On the frontline, from our first day, this defense line has been mobilized immediately and in a non -specific manner in the presence of infectious pathogens. However, the signaling mechanisms of this quick response are complex: their irregularities can cause automatic diseases and chronic inflammatory diseases.
Andrea Ablasar and his team’s job seeks to understand how this response has been arranged at a cellular level to develop a new treatment strategy.
CGAS Sting Signaling Way: An important method of natural immunity
Andrea Ablassar is one of the researchers who, in 2013, discovered a new signaling path included in the CGAS path, in 2013, (Dizziness GMP-AMP synthesis) -Staing (The stimulus of interferon genes) In the case of viral DNA interference in our body cells, two proteins that form together a high -speed intervention team: CGAS alerts and active stains, which immune response in the form of inflammation Causes .
Double Edge: Risks of inappropriate Activation
If the CGAS sting route is necessary to defend our organization against viral infection, it can change against it when it is incorrectly activated. Under a potential error, stress, aging or the effect of some diseases: CGA then confuses our own DRNA that the “foreigner” survived the cell nucleus with DNA. Warning, the dancing stimulates an excessive inflammatory response, which can cause autoimmune or neurodegenerative diseases.
Promise to therapeutic
Thanks to an intercontinental approach to structural biology, biochemistry and bio-information, Andrea Ablaser and his team identified two molecules that are capable of preventing immune activation through CGAS-setting. These discoveries can be promised that can allow new treatment to deal with autoimmune diseases and some forms of cancer.
Article written in partnership with Batchenwart Shuler Foundation
