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Alternative of hemp without addiction or side effects? This may eventually be possible!

What if the pain can be relieved without side effects or dependence? Researchers may find solutions in a compound with new features.

Today, in many parts of the world, opioids occupy an important location in the treatment of pain, but their prolonged use is the main risks of dependence and side effects.

Although the popularity of therapeutic treatment has increased, some researchers have begun to seek a safe alternative without a psychological effect. A team of Scientists at the University of Washington, in St. Louis, and could find a draft solution to Stanford University. Their discovery, appeared in the review on March 5 NatureWithout brain intoxication or changes, reports modern pain -reducing pain.

An alternative to therapeutic that does not enter the brain

Treatment hempoxes works thanks to cannabinoids, UnrulyUnruly Which is binding to receptors in the body, especially in the brain and pain related nerve cells. By fixing themselves on these receptors, they can change the impression of pain. However, this effect can also have mood changes, dependence and other unwanted side effects.

Researchers have developed a compound that imitates the effects of natural cannabinoids, but with a significant difference: it does not cross it hémato-encephalic barrierhémato-encephalic barrierWhich separates BrainBrain The rest of the body “” The compound we have prepared attaches to the receptors that reduce the pain in the body but it cannot reach the brain. This means that it avoids psychological side effects such as mood changes and does not cause dependence because it does not work at the center of the brain’s reward. “Principal author of this study describes Professor Susrata Majumdar.

Encouraging results in mice

During the tests, mice were injected for nine days with a compound twice a day. Consequent: A significant reduction in pain in mice suffering from nerve injuries and migrants, without promoting addiction.

Researchers now intend to continue the development of this compound so that it can be converted into oral medicines. The purpose is to start Clinical trialsClinical trials Assessing its effect in humans. If it leads to research, this drug can offer a revolutionary alternative to current pain -reducing, especially in the context of chronic pain management.

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